Complications of Amniocentesis in Northwest IRAN

  • Simin Taghavi Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sharareh Barband Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • Hossein Alikhah Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Naghavi-Behzad Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Armin Zarrintan Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shima Khan-Ahmadi Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • Nazanin Cham-Heidar Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • Reza Piri Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords: Amniocentesis, Complications, Prenatal diagnosis

Abstract

Objective: Although prenatal diagnosis by amniocentesis has been accepted as a reliable and low risk method, it is still an invasive diagnostic procedure and carries the risk for procedure-related complications. This study aimed to evaluate the relation of amniocentesis with early (before 20th week) and late (after 20th week) pregnancy complications.

Methods: Present study used a case control design conducted on consecutive pregnant patients scheduled for diagnostic amniocentesis (n=920), and patients who had counseling in the same period but did not undergo amniocentesis (n=426). The early complications were defined as those occurring during the first 7 days after procedure including miscarriage, spotting, and vaginal bleeding (as occurring in a menstrual period). The late complications were those occurring after 20th week of gestation, or vaginal bleeding after 7 days following the procedure.

Results: A total of 920 pregnant women were included as case group, of which 58.7% presented before 18th week and 41.3% presented after 18th week of GA for evaluating fetal genetic status. The most prevalent GA for this process was 16th week (15-23w). The early complications were water breaks (0%), Abortion (0.8%), spotting (0.3%), and vaginal bleeding (0.1%) during 7 days after sampling.

The late complications were water breaks (1.6%), Abortion (0%), spotting (0%), and vaginal bleeding (1.8%) after 20th week.

Conclusion: Evaluating complications of amniocentesis in Northwest of IRAN revealed acceptable rate of early and late complications. This is because of high-volume performance in this tertiary centre in expert hands. Considering the ethical and religious limitations we do recommend using first trimester screening methods in Islamic countries to get earlier results.

Published
2015-07-14
Section
Research Articles