The Efficacy of Misoprostol Plus Vasopressin Versus Vasopressin Alone on Surgical Outcomes Through Minimally Invasive Myomectomy: Research Protocol

  • Zohreh Tavana Department of Obstetrics & Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
  • Parnian Kordjamshidi
  • Saeed Alborzi
Keywords: leiomyoma, fibroids, laparascopy, blood loss, misoprostol, myomectomy


To compare the effect of perivascular vasopressin with a combination of rectal misoprostol plus perivascular vasopressin on blood loss reduction during minimally invasive myomectomies, a double-blind randomized clinical trial it designed to be conducted in Shiraz, Iran in 2015. The primary outcomes of the study include; blood loss during surgery and hemoglobin (Hb) drop after surgery extracting the baseline and 6-hour post-surgery serum hemoglobin levels. The secondary outcomes of the study include; duration of operation; surgical complications; post-operative complications; hemodynamic changes during surgery, administration of other uterotonic agents; and post-operative fever.
Research Protocols