Correlation of tumor-associated tissue eosinophilia and blood eosinophil counts with tumor grade,size and lymph node involvement in oral squamous cell carcinoma

  • Amirala Aghbali Associate Professor,Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sepideh Vosough Hosseini Professor,Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Ali Taghavi Zenouz Associate Professor,Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Monireh Halimi Associate Professor ,Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  • Zohreh Sanaat Assistant Professor,Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shirin Fattahi Assistant Professor,Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shabnam Khalifezadeh Dentist,Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords: Squamous cell carcinoma, eosinophils, tumor grade

Abstract

Purpose: To assess the correlation of Tumor-Associated Tissue Eosinophilia (TATE) and  blood eosinophil counts with tumor grade, size, and local lymph node involvement 

Methods:In the present study, forty-three patients with a diagnosis of oral SCC were evaluated. TATE was determined in ten random fields under ×40 magnification(stained with H&E). Laboratory tests of the patients were also evaluated one day before surgery and after three, six and twelve weeks since surgery. In the next step, TATE were determined under a light microscope in ten random fields under ×40 magnification by two pathologists.Data were analyzed using descriptive statistical methods (mean ± standard deviation), N (%) and repeated measures ANOVA, Pearson’s correlation coefficient and chi-squared tests. Statistical significance was defined at p<0.05.

Results: TATE was correlated with tumor grade (P=0.03), but it was not correlated with tumor size and lymph node involvement. In the analysis of peripheral blood eosinophil counts , a correlation was observed with lymph node involvement (P = 0.023), but no correlation was noted with the tumor grade or size. In addition, peripheral blood analysis revealed that peripheral blood eosinophil counts were significantly different 1 day before surgery and 6 and 12 weeks after surgery.

Conclusions: The results of the present study showed that there is a correlation between TATE and oral SCC grades. In addition, blood eosinophil counts were correlated with lymph node involvement.

 

 

 

Published
2013-10-01
Section
Research Articles